Stem Cell Meet 2024 | Scientific Sessions | Advancements in Tissue Engineering and Regenerative Medicine

Stem Cell Therapy

Stem cell therapy is a branch of regenerative medicine that involves the use of stem cells to treat or prevent diseases and injuries. Stem cells are undifferentiated cells that have the ability to differentiate into different cell types and regenerate damaged tissues. This therapy holds significant potential for the treatment of a wide range of medical conditions.

• Types of Stem Cells: Stem cells can be derived from various sources, including embryonic tissue, adult tissues (such as bone marrow or adipose tissue), and induced pluripotent stem cells (iPSCs) generated by reprogramming adult cells. Each source has its advantages and considerations regarding availability, potential to differentiate, and ethical considerations.

• Differentiation and Specialization: Stem cells have the unique ability to differentiate into specialized cell types, such as neurons, muscle cells, or blood cells. This property allows them to replace or repair damaged tissues and organs.

•Therapeutic Applications: Stem cell therapy has shown promise in treating a range of medical conditions, including degenerative diseases (such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis), cardiovascular disorders, orthopedic injuries, autoimmune diseases, and certain types of cancer.

• Modes of Administration: Stem cells can be delivered to the body through various methods, including intravenous injection, local injection into the target tissue, or surgical transplantation.

•Immune Compatibility: When using allogeneic stem cells (stem cells derived from another person), there is a risk of immune rejection. Researchers are exploring strategies to mitigate this response, such as using immunosuppressive drugs or utilizing autologous stem cells (stem cells derived from the patient's own body).

• Clinical Trials and Research: Stem cell therapy is an active area of research, with ongoing clinical trials to evaluate its safety, efficacy, and long-term effects. These trials help determine the optimal cell types, dosage, delivery methods, and patient selection criteria for different conditions.

• Ethical Considerations: The use of embryonic stem cells raises ethical concerns due to the destruction of embryos. However, adult stem cells and iPSCs offer alternative ethical sources for therapy.

• Regulatory Landscape: The regulation of stem cell therapy varies across countries and regions. Regulatory authorities aim to ensure patient safety, ethical considerations, and proper informed consent in stem cell research and therapy.

Keywords: #Stem cells; #Therapy; #Regenerative medicine; #Transplantation; #Cell-based therapy;#Tissue engineering; #Cell differentiation; #Cell replacement;#Disease treatment; #Mesenchymal stem cells; #Hematopoietic stem cells; #Induced pluripotent stem cells; #Gene therapy; #Ethical considerations; #Safety; #Efficacy; #Personalized medicine ; #Stem cell niche

List of Journals: #Stem Cell Reports; #Cell Stem Cell; #Stem Cell Research; #RegenerativeMedicine; #Tissue Engineering; #Biomaterials ; #Journal of Stem Cell Research Therapy; #Cytotherapy; #Journal of Regenerative Medicine;#Current Stem Cell Research Therapy; #Stem Cell Research and Therapy; #Stem Cell Reviews and Reports; #Journal of Translational Medicine;

List of stem cell foundations and organizations: #Harvard Stem Cell Institute (United States); #University of California, San Francisco (UCSF) Stem Cell Center (United States); #MRC Centre for Regenerative Medicine, University of Edinburgh (United Kingdom);#Center for Stem Cell and Regenerative Medicine, The Ohio State University (United States);

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cell Embryology

Stem cell embryology is a field of study that focuses on the development and differentiation of embryonic stem cells during embryogenesis. Embryonic stem cells (ESCs) are derived from the inner cell mass of the blastocyst stage of early embryos and have the unique ability to differentiate into any cell type in the body.

Here are some key points about stem cell embryology:

• Source of Embryonic Stem Cells: Embryonic stem cells are typically obtained from surplus embryos donated by couples undergoing in vitro fertilization (IVF) treatments. These embryos are created in the laboratory through fertilization of eggs with sperm.

• Pluripotency: Embryonic stem cells are pluripotent, meaning they have the potential to differentiate into cells of all three germ layers: ectoderm, endoderm, and mesoderm. This characteristic makes them highly valuable for regenerative medicine and developmental biology research.

• Early Development: Stem cell embryology studies the early stages of embryonic development, including the formation of germ layers, gastrulation, and organogenesis. By understanding the mechanisms that govern these processes, researchers can gain insights into cell fate determination and tissue formation.

• Differentiation Potential: Embryonic stem cells can be induced to differentiate into specific cell types under controlled laboratory conditions. This process involves exposing the cells to specific signaling molecules and growth factors that mimic the natural developmental cues found in the embryo.

• Developmental Signaling Pathways: Stem cell embryology research focuses on studying the molecular and cellular mechanisms involved in developmental signaling pathways, such as Wnt, BMP, and Notch pathways. These pathways regulate cell fate decisions and control the differentiation of embryonic stem cells into specific lineages.

• Disease Modeling: Embryonic stem cells can be used to create in vitro models of human diseases, allowing researchers to study disease mechanisms and test potential therapeutic interventions. By differentiating embryonic stem cells into specific cell types affected by a disease, researchers can gain insights into disease progression and screen drugs for efficacy.

• Ethical Considerations: The use of embryonic stem cells raises ethical considerations due to the destruction of embryos. However, recent advances in induced pluripotent stem cell (iPSC) technology provide an alternative approach, allowing researchers to reprogram adult cells into an embryonic-like state.

• Clinical Applications: Stem cell embryology research has the potential to contribute to the development of regenerative therapies for various diseases and injuries. By understanding the mechanisms of embryonic development, researchers can guide the differentiation of stem cells towards specific cell types needed for tissue repair and regeneration.

Keywords: #In vitro differentiation; #Biomaterials; #Stem cell banking; #Stem cell manufacturing; #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids

List of stem cell foundations and organizations: #RIKEN Center for Developmental Biology (Japan); #Monash University (Australia); #Center for Regenerative Medicine, The Scripps Research Institute (United States); #Fred Hutchinson Cancer Research Center, Stem Cell and Gene Therapy Program (United States); #Centre for Stem Cell Research; A*STAR (Agency for Science, Technology, and Research) (Singapore)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Stem Cell Banking

Stem cell banking, also known as stem cell preservation or cryopreservation, involves the collection and storage of stem cells for future medical use. Stem cells can be obtained from various sources, including umbilical cord blood, bone marrow, and adipose tissue. Stem cell banks collect and process these cells, preserving them in specialized facilities at ultra-low temperatures to maintain their viability. Stem cell banking provides a valuable resource for potential future therapies, as these preserved cells can be utilized in regenerative medicine or treatment of diseases. It offers a form of biological insurance, allowing individuals to secure their own or their family's access to potentially life-saving stem cell treatments in the future.

Here are some key points about stem cell banking:

• Types of Stem Cell Banks: There are primarily two types of stem cell banks: public and private. Public stem cell banks collect and store donated stem cells, making them available for anyone in need. Private stem cell banks store stem cells exclusively for the individual or their family's use.

• Sources of Stem Cells: The most commonly banked stem cells are hematopoietic stem cells, which can be collected from various sources such as umbilical cord blood, bone marrow, and peripheral blood. These sources are rich in stem cells and can be harvested during childbirth or through other medical procedures.

• Cord Blood Banking: Umbilical cord blood banking is a popular form of stem cell banking. After a baby is born, the blood remaining in the umbilical cord and placenta is collected, processed, and stored for potential future use. Cord blood is a rich source of hematopoietic stem cells, which can be used in the treatment of certain blood disorders, immune system diseases, and genetic disorders.

• Indications for Stem Cell Transplantation: Stem cell transplantation is commonly used to treat various conditions, including leukemia, lymphoma, genetic disorders, bone marrow failure syndromes, and certain immune system disorders. Banked stem cells can provide a valuable source of cells for transplantation when a suitable donor match is not available.

• Private Stem Cell Banking: Private stem cell banking allows individuals to store their own stem cells for potential future use. This can provide a personalized and readily available source of stem cells for autologous transplantation, should the need arise. The decision to pursue private stem cell banking is a personal one and involves considering the potential benefits and costs.

• Public Stem Cell Banking: Public stem cell banks collect and store donated stem cells for use by patients in need of a stem cell transplant. These banks provide a registry of available stem cell units that can be matched with patients based on compatibility. Donating stem cells to a public bank is a selfless act that can potentially save the lives of others.

• Considerations and Limitations: Stem cell banking has its limitations, and not all conditions can be treated with banked stem cells. It is important to understand the specific indications and limitations of stem cell transplantation for different diseases. Additionally, the long-term viability and effectiveness of stored stem cells may vary, and ongoing research is conducted to improve storage techniques and outcomes.

Keywords: #Tissue engineering; #Stem cells; #Cell therapy; #Biomaterials; #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation; #Cellular therapy; #Bioprinting; #Organ transplantation; #Disease modeling; #Personalized medicine

List of Journals: #Stem Cell Reports; #Cell Stem Cell; #Stem Cell Research; #Regenerative Medicine; #Tissue Engineering; #Journal of Stem Cell Research & Therapy; #Cytotherapy; #Journal of Regenerative Medicine; #Stem Cell Research and Therapy; #Stem Cell Reviews and Reports; #Journal of Translational Medicine; #Molecular Therapy; #Frontiers in Cell and Developmental Biology

List of stem cell foundations and organizations: #Centre for Stem Cell Research, A*STAR (Agency for Science, Technology, and Research) (Singapore); #Wyss Institute for Biologically Inspired Engineering - Harvard University; #Center for Regenerative Medicine - Massachusetts General Hospital; #Stem Cell and Regenerative Medicine Center - University of Wisconsin-Madison; #Wake Forest Institute for Regenerative Medicine

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cells Beat COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has infected millions in the COVID-19 pandemic. Stem cell therapy may treat COVID-19. Stem cells, with their regenerative and immunomodulatory abilities, can help patients recover from the virus and its consequences. Stem cells are used to fight COVID-19.

Stem cells have shown promise in the fight against COVID-19. Researchers are exploring the use of mesenchymal stem cells (MSCs), which have potent immunomodulatory and regenerative properties. MSCs can modulate the immune response, reducing inflammation and promoting tissue repair. In COVID-19, where an overactive immune response can lead to severe lung damage, MSCs may help mitigate the harmful effects. Preliminary studies and clinical trials have demonstrated encouraging results, with MSCs showing potential in improving lung function, reducing inflammation, and enhancing patient recovery. However, further research is needed to establish the safety, efficacy, and optimal administration protocols for stem cell-based therapies in COVID-19. Stem cells offer a promising avenue for developing novel treatments to combat the global pandemic.

Keywords #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation; #Cellular therapy; #Bioprinting; #Organ transplantation; #Wound healing; #Biomarkers; #Disease modeling; #Clinical trials; #Personalized medicine

Journals: #Biotechnology Advances; #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology; #Journal of Materials Science: Materials in Medicine; #Journal of Biomechanics; #Scientific Reports (Nature)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Stem Cell Nanotechnology

Stem cell nanotechnology combines the fields of stem cell biology and nanotechnology to develop innovative approaches for enhancing the therapeutic potential of stem cells. Nanotechnology involves manipulating materials and structures at the nanoscale, enabling precise control over stem cell behavior and interactions. Nanomaterials can be engineered to deliver therapeutic agents, guide stem cell differentiation, or provide structural support in tissue engineering. Nanoparticles and nano sensors enable targeted drug delivery, real-time monitoring of stem cell behavior, and high-resolution imaging. By harnessing the unique properties of nanomaterials, stem cell nanotechnology aims to improve the efficacy, safety, and precision of stem cell-based therapies, paving the way for advancements in regenerative medicine and personalized healthcare. Continued research in stem cell nanotechnology holds great promise for addressing complex diseases and accelerating the development of novel treatments.

Keywords: #Biomaterials; #Stem cell banking; #Stem cell manufacturing; #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation; #Biomimetic materials; #Tissue scaffolds; #Decellularization

List of Journals: #Stem Cell Reports; #Cell Stem Cell; #Stem Cell Research; #Regenerative Medicine; #Tissue Engineering; #Biomaterials; #Journal of Stem Cell Research & Therapy; #Cytotherapy; #Journal of Regenerative Medicine; #Current Stem Cell Research & Therapy; #Stem Cell Research and Therapy; #Stem Cell Reviews and Reports

List of stem cell foundations and organizations: #Alliance for Regenerative Medicine (ARM); #National Stem Cell Foundation (NSCF); #Stem Cell Foundation (Australia); #Stem Cell & Regenerative Medicine Consortium (SRMC); #Massachusetts Stem Cell Bank and Registry; #German Stem Cell Network (GSCN); #Stem Cell Society Singapore

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Stem Cell Biotechnology and Cloning

Stem cell biotechnology and cloning are two related but distinct fields that have significant implications for scientific research and potential applications in medicine. Stem cell biotechnology focuses on the isolation, manipulation, and utilization of stem cells for therapeutic purposes. Stem cells have the unique ability to differentiate into various cell types in the body, making them valuable for regenerative medicine, disease modeling, and drug discovery. Biotechnologists employ techniques such as cell culture, genetic engineering, and tissue engineering to expand stem cell populations, induce their differentiation, and develop methods for transplantation or integration into damaged tissues.

Cloning, on the other hand, involves the creation of genetically identical copies of organisms or specific cells. There are two primary types of cloning: reproductive cloning and therapeutic cloning. Reproductive cloning aims to create an entire organism with the same genetic makeup as the donor. Therapeutic cloning, also known as somatic cell nuclear transfer (SCNT), involves creating embryonic stem cells that are genetically identical to the donor. These stem cells can be used for research, drug testing, or potentially for personalized cell therapies.

While both stem cell biotechnology and cloning have potential applications in regenerative medicine and research, cloning techniques, particularly reproductive cloning, have been the subject of ethical debates and regulatory restrictions. The focus has shifted towards ethical uses of stem cells, such as the production of induced pluripotent stem cells (iPSCs) from adult cells, which avoid the ethical concerns associated with embryo destruction. Continued research and ethical considerations are necessary to harness the full potential of stem cell biotechnology and ensure responsible applications of cloning techniques.

Keywords: #Stem cells; #Therapy; #Regenerative medicine; #Transplantation; #Cell-based therapy; #Tissue engineering; #Cell differentiation; #Cell replacement; #Disease treatment; #Cellular therapy; #Stem cell transplantation; #Stem cell-based regenerative therapy; #Immunomodulation; #Cell regeneration; #Clinical trials; #Stem cell sources

List of stem cell foundations and organizations: #Harvard Stem Cell Institute (United States); #University of California, San Francisco (UCSF) Stem Cell Center (United States); #Center for Stem Cell Biology and Regenerative Medicine, Washington University in St. Louis (United States); #Centre for Stem Cells and Regenerative Medicine, King's College London (United Kingdom)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Epigenetics and Genetics of Stem Cells

Epigenetics and genetics play crucial roles in the regulation and maintenance of stem cells. They provide a deeper understanding of the mechanisms that control stem cell behavior, including self-renewal and differentiation.

Epigenetics and genetics are intertwined in the regulation of stem cells. Stem cells inherit their genetic information, stored in the DNA, from parent cells during cell division. However, epigenetic modifications, such as DNA methylation and histone modifications, also play a crucial role in determining gene expression patterns in stem cells. These modifications can turn genes on or off, influencing stem cell fate decisions, self-renewal, and differentiation. The interplay between epigenetic and genetic factors is essential for maintaining the balance between stemness and differentiation in stem cells. Understanding the complex interactions between epigenetics and genetics provides insights into stem cell behavior and has implications for regenerative medicine and disease research.

Keywords: #Stem cell manufacturing; #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation; #Biomimetic materials; #Tissue scaffolds; #Decellularization; #Tissue morphogenesis; #Bioreactors; #Vascularization

List of Journals: #Journal of Translational Medicine; #Molecular Therapy; #Frontiers in Cell and Developmental Biology; #Nature Communications; #Science Translational Medicine; #PLOS ONE; #Acta Biomaterialia; #Biomaterials Science; #Advanced Healthcare Materials; #Advanced Drug Delivery Reviews; #Journal of Biomedical Materials Research Part A

List of stem cell foundations and organizations: #MRC Centre for Regenerative Medicine, University of Edinburgh (United Kingdom); #Center for Stem Cell and Regenerative Medicine, The Ohio State University (United States); #Center for Stem Cell Research, University of Texas Health Science Center at Houston (United States); #RIKEN Center for Developmental Biology (Japan); #Center for Stem Cell Research, Chinese Academy of Sciences (China)<

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Stem Cell Apoptosis & Signal Transduction

Apoptosis, or programmed cell death, is a crucial process in stem cell biology that regulates cell population and maintains tissue homeostasis. Signal transduction pathways play a vital role in controlling apoptosis in stem cells. Various external and internal cues, such as growth factors, cytokines, or cellular stress, activate signaling cascades that ultimately determine whether a stem cell survives or undergoes apoptosis. These pathways involve the activation of specific receptors, intracellular signaling molecules, and transcription factors that regulate the expression of genes involved in apoptosis. Understanding the intricate signaling networks that govern stem cell apoptosis is essential for manipulating cell survival and optimizing stem cell-based therapies.

Keywords: #Immunomodulation; #Tissue engineering; #Stem cells; #Cell therapy; #Biomaterials; #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation; #Cellular therapy; #Bioprinting; #Organ transplantation; #Wound healing; #Biomarkers; #Disease modeling; #Clinical trials; #Personalized medicine

List of stem cell foundations and organizations: #Monash University (Australia); #Center for Regenerative Medicine, The Scripps Research Institute (United States); #Fred Hutchinson Cancer Research Center, Stem Cell and Gene Therapy Program (United States); #Centre for Stem Cell Research, A*STAR (Agency for Science, Technology, and Research) (Singapore); #Wyss Institute for Biologically Inspired Engineering - Harvard University; #Center for Regenerative Medicine - Massachusetts General Hospital

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cells in Disease and Treatment

Stem cells have immense potential in understanding and treating various diseases. In the context of regenerative medicine, stem cells hold promise for replacing damaged or dysfunctional tissues. For example, in conditions such as heart disease, neurological disorders, or bone defects, stem cells can be harnessed to regenerate damaged tissues and restore their functionality.

Additionally, stem cells are valuable tools for disease modeling and drug discovery. Induced pluripotent stem cells (iPSCs), generated by reprogramming adult cells, can be differentiated into specific cell types affected by a particular disease. This enables researchers to study disease mechanisms, screen potential therapeutic compounds, and personalize treatments based on a patient's specific genetic background.

Furthermore, stem cell transplantation is being explored as a treatment for certain cancers, such as leukemia, where stem cells from a compatible donor can replace the patient's diseased bone marrow. In autoimmune diseases, stem cell transplantation aims to reset the immune system and alleviate symptoms.

While still a rapidly evolving field, stem cell research offers promising avenues for improving disease understanding, developing new treatments, and advancing personalized medicine approaches.

Keywords: #Biomaterials; #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation; #Cellular therapy; #Bioprinting; #Organ transplantation; #Wound healing; #Biomarkers; #Disease modeling; #Clinical trials; #Personalized medicine

List of Journals: #Journal of Biomedical Materials Research Part A; #Regenerative Medicine; #Journal of Cellular and Molecular Medicine; #Journal of Biomaterials Applications; #Biotechnology Advances; #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology

List of stem cell foundations and organizations: #Stem Cell and Regenerative Medicine Center - University of Wisconsin-Madison; #Institute of Biomaterials and Biomedical Engineering - University of Toronto; #Center for Regenerative Therapies Dresden - Technische Universität Dresden; #Wake Forest Institute for Regenerative Medicine; #Center for Cellular and Molecular Engineering - University of Pittsburgh;

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Regenerative Medicine and Tissue Engineering

Regenerative medicine and tissue engineering are interdisciplinary fields that aim to restore, replace, or regenerate damaged or diseased tissues and organs. These fields utilize various approaches, including stem cell therapy, biomaterials, and tissue engineering techniques, to promote tissue regeneration and functional restoration.

Stem cells play a crucial role in regenerative medicine, as they possess the ability to differentiate into different cell types and promote tissue repair. They can be guided to differentiate into specific cell lineages and integrated into damaged tissues to promote regeneration.

Tissue engineering focuses on creating functional tissues and organs in the laboratory by combining cells, biomaterial scaffolds, and growth factors. These engineered tissues can then be transplanted into patients, offering a potential solution for organ transplantation shortages.

Both regenerative medicine and tissue engineering offer promising prospects for treating a wide range of conditions, including cardiovascular diseases, neurodegenerative disorders, musculoskeletal injuries, and organ failure. While still in the research and development stages, these fields hold great potential to revolutionize healthcare by providing innovative solutions for tissue repair and replacement.

List of stem cell foundations and organizations: #Institute for Stem Cell Science and Regenerative Medicine - National Centre for Biological Sciences (India); #Center for Regenerative Medicine - Mayo Clinic; #McEwen Centre for Regenerative Medicine - University Health Network (Canada); #California Institute for Regenerative Medicine (CIRM); #International Society for Stem Cell Research (ISSCR)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Stem Cell Bioengineering

Stem cell bioengineering combines the principles of stem cell biology and engineering to develop novel approaches for manipulating and directing stem cell behavior. This interdisciplinary field aims to enhance the functionality and therapeutic potential of stem cells for various applications.

Bioengineers utilize a range of techniques to engineer stem cells, including genetic engineering, biomaterial design, and microfluidics. These approaches can be employed to control stem cell fate decisions, enhance their survival and engraftment, or promote specific differentiation pathways.

Stem cell bioengineering has the potential to revolutionize regenerative medicine by providing precise control over stem cell behavior and tissue regeneration. It offers opportunities for developing tailored cell-based therapies, drug screening platforms, and disease models. Continued research in stem cell bioengineering holds promise for advancing the field and translating these technologies into clinical applications for improved patient care and outcomes.

Keywords: #3D bioprinting; #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation; #Biomimetic materials; #Tissue scaffolds; #Decellularization; #Tissue morphogenesis; #Bioreactors; #Vascularization; #Immunomodulation; #Tissue engineering; #Stem cells; #Cell therapy; #Biomaterials; #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation

List of Journals: #Science Translational Medicine; #PLOS ONE; #Acta class=SpellE>Biomaterialia; #Biomaterials Science; #Advanced Healthcare Materials; #Advanced Drug Delivery Reviews; #Journal of Biomedical Materials Research Part A; #Regenerative Medicine; #Journal of Cellular and Molecular Medicine; #Journal of Biomaterials Applications; #Biotechnology Advances

List of stem cell foundations and organizations: #International Society for Stem Cell Research (ISSCR); #New York Stem Cell Foundation (NYSCF); #EuroStemCell; Stem Cell Network (SCN); #Alliance for Regenerative Medicine (ARM); #National Stem Cell Foundation (NSCF); #Stem Cell Foundation (Australia); #Stem Cell & Regenerative Medicine Consortium (SRMC); #Massachusetts Stem Cell Bank and Registry; #German Stem Cell Network (GSCN); #Stem Cell Society Singapore.

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Stem Cell & Pediatric Transplantation

Stem cell transplantation plays a crucial role in pediatric medicine, offering a potentially curative treatment for a variety of conditions in children. Pediatric stem cell transplantation involves the infusion of healthy stem cells into a child's body to replace damaged or dysfunctional cells.

This procedure is commonly used in the treatment of pediatric cancers, such as leukemia and lymphoma, where high-dose chemotherapy or radiation therapy is employed to eradicate cancer cells but also damages healthy bone marrow. Stem cell transplantation can replenish the bone marrow with healthy cells and restore blood cell production.

Additionally, stem cell transplantation is used to treat inherited disorders, such as immune deficiencies, metabolic diseases, and certain genetic disorders, by providing functional cells to replace the defective ones.

Pediatric stem cell transplantation requires specialized expertise and tailored approaches to address the unique needs of young patients. Advances in stem cell research and transplantation techniques continue to improve outcomes and offer hope for children with life-threatening conditions.

Keywords: #Tissue morphogenesis; #Bioreactors; #Vascularization; #Immunomodulation; #Tissue engineering; #Stem cells; #Cell therapy; #Biomaterials; #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation; #Cellular therapy; #Bioprinting

List of Journals: #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology; #Journal of Materials Science: Materials in Medicine; #Journal of Biomechanics; #Scientific Reports (Nature).

List of stem cell foundations and organizations: #California Institute for Regenerative Medicine (CIRM); #International Society for Stem Cell Research (ISSCR); #New York Stem Cell Foundation (NYSCF); #EuroStemCell; Stem Cell Network (SCN); #Alliance for Regenerative Medicine (ARM); #National Stem Cell Foundation (NSCF); #Stem Cell Foundation (Australia)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Stem Cell-Based Drug Discovery

Stem cell-based drug discovery is a revolutionary approach that leverages the potential of stem cells to accelerate the development of new drugs. Stem cells, particularly induced pluripotent stem cells (iPSCs), can be derived from patient samples and differentiated into specific cell types affected by a disease or condition. These cells serve as powerful tools for disease modeling, allowing researchers to study disease mechanisms, test drug efficacy and safety, and identify potential therapeutic targets.

By using stem cells to create disease-specific models in the laboratory, researchers can gain insights into disease progression, screen potential drug candidates, and personalize treatment approaches based on an individual's genetic background. This approach enables more accurate and efficient drug development, reducing the reliance on animal models and increasing the likelihood of success in clinical trials.

Stem cell-based drug discovery holds tremendous potential for improving the efficiency and effectiveness of the drug development process, leading to the identification of safer and more targeted therapies for a wide range of diseases, including cancer, neurodegenerative disorders, and genetic conditions.

List of Journals: #Molecular Therapy; #Frontiers in Cell and Developmental Biology; #Nature Communications; #Science Translational Medicine; #PLOS ONE; #Acta Biomaterialia; #Biomaterials Science; #Advanced Healthcare Materials; #Advanced Drug Delivery Reviews; #Journal of Biomedical Materials Research Part A; #Regenerative Medicine; #Journal of Cellular and Molecular Medicine; #Journal of Biomaterials Applications; #Biotechnology Advances

List of stem cell foundations and organizations: #RIKEN Center for Developmental Biology (Japan); #Center for Regenerative Medicine and Stem Cell Research - University of California, Davis; #Institute for Stem Cell Science and Regenerative Medicine - National Centre for Biological Sciences (India); #Center for Regenerative Medicine - Mayo Clinic; #McEwen Centre for Regenerative Medicine - University Health Network (Canada); #California Institute for Regenerative Medicine (CIRM); #International Society for Stem Cell Research (ISSCR); #New York Stem Cell Foundation (NYSCF)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Regeneration & Therapeutics

Regeneration and therapeutics intersect in the field of regenerative medicine, which focuses on harnessing the body's natural healing mechanisms to restore damaged tissues and organs. Regenerative therapeutics aim to replace or repair tissues affected by injury, disease, or age-related degeneration.

The goal of regenerative therapeutics is to not only restore tissue structure but also restore functionality and improve patients' quality of life. While still in the early stages, regenerative therapeutics hold tremendous promise for addressing a wide range of conditions, including cardiovascular disease, neurodegenerative

Keywords: #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation; #Biomimetic materials; #Tissue scaffolds; #Decellularization; #Tissue morphogenesis; #Bioreactors; #Vascularization; #Immunomodulation; #Tissue engineering; #Stem cells; #Cell therapy; #Biomaterials; #Regeneration; #Repair

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Diseases and Stem Cell Treatment

Stem cell treatment holds great potential for addressing a wide range of diseases. In conditions like leukemia and other blood disorders, stem cell transplantation can replace damaged bone marrow with healthy stem cells. In neurodegenerative disorders like Parkinson's or spinal cord injuries, stem cells may offer regenerative effects to repair damaged neural tissues. Stem cell therapy also shows promise in treating cardiovascular diseases, diabetes, autoimmune disorders, and liver diseases. Moreover, ongoing research explores the use of stem cells for tissue engineering and organ regeneration. While challenges remain, stem cell treatment offers a promising avenue for improving patient outcomes and advancing the field of regenerative medicine.

Keywords: #Induced pluripotent stem cells; #Gene therapy; #Ethical considerations; #Safety; #Efficacy; #Personalized medicine; #Stem cell niche; #In vitro differentiation; #Biomaterials; #Stem cell banking; #Stem cell manufacturing; #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials

List of stem cell foundations and organizations: #McEwen Centre for Regenerative Medicine - University Health Network (Canada); #California Institute for Regenerative Medicine (CIRM); #International Society for Stem Cell Research (ISSCR); #New York Stem Cell Foundation (NYSCF); #EuroStemCell; Stem Cell Network (SCN); #Alliance for Regenerative Medicine (ARM); #National Stem Cell Foundation (NSCF)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Cancer Stem Cell and Oncology

Cancer stem cells are a small subset of cells within tumors that possess stem cell-like properties, including self-renewal and the ability to differentiate into multiple cell types within the tumor. They are believed to play a crucial role in tumor initiation, progression, and resistance to treatment. Understanding cancer stem cells is essential for developing targeted therapies to eradicate these cells and prevent tumor recurrence. Researchers are investigating various approaches to target cancer stem cells, such as inhibiting key signaling pathways, disrupting their self-renewal capabilities, and inducing their differentiation into non-cancerous cell types. By specifically targeting cancer stem cells, the hope is to improve treatment outcomes, reduce relapse rates, and ultimately advance the field of oncology.

List of Journals: #Regenerative Medicine; #Journal of Cellular and Molecular Medicine; #Journal of Biomaterials Applications; #Biotechnology Advances; #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology; #Journal of Materials Science: Materials in Medicine

List of stem cell foundations and organizations: #Fred Hutchinson Cancer Research Center, Stem Cell and Gene Therapy Program (United States); #Centre for Stem Cell Research, A*STAR (Agency for Science, Technology, and Research) (Singapore); #Wyss Institute for Biologically Inspired Engineering - Harvard University

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Novel Stem Cell Technologies

Novel stem cell technologies are continuously emerging, offering exciting advancements in the field of regenerative medicine. One notable development is the use of gene editing techniques, such as CRISPR-Cas9, to modify stem cells and correct genetic abnormalities associated with inherited diseases. This holds promise for personalized cell therapies and disease modeling. Additionally, 3D bioprinting enables the creation of complex, functional tissues by depositing stem cells and biomaterials layer by layer. This technology has the potential to revolutionize tissue engineering and organ transplantation. Furthermore, advances in single-cell analysis techniques allow researchers to characterize and study individual stem cells, uncovering heterogeneity and identifying specific cell populations for targeted therapies. These novel technologies expand the possibilities and applications of stem cell research, bringing us closer to transformative medical treatments.

Keywords: #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation; #Biomimetic materials; #Tissue scaffolds; #Decellularization

List of Journals: #Journal of Cellular and Molecular Medicine; #Journal of Biomaterials Applications; #Biotechnology Advances; #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology; #Journal of Materials Science: Materials in Medicine

List of stem cell foundations and organizations: #New York Stem Cell Foundation (NYSCF); #EuroStemCell; Stem Cell Network (SCN); #Alliance for Regenerative Medicine (ARM); #National Stem Cell Foundation (NSCF); #Stem Cell Foundation (Australia); #Stem Cell Regenerative Medicine Consortium (SRMC); #Massachusetts Stem Cell Bank and Registry; #German Stem Cell Network (GSCN)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Reprogramming Stem Cells: Computational Biology

Reprogramming stem cells through computational biology is an emerging field that combines computational modeling and experimental techniques to manipulate cellular identity. By analyzing large-scale datasets, computational biologists can identify key molecular factors and signaling pathways involved in cell fate determination. This knowledge is used to design protocols that reprogram mature cells into induced pluripotent stem cells (iPSCs) or convert one cell type directly into another without going through a pluripotent state. Computational models provide insights into the underlying mechanisms and guide the optimization of reprogramming protocols. This approach holds great potential for generating patient-specific iPSCs for disease modeling, drug discovery, and regenerative medicine. Computational biology offers a powerful tool to unravel the complex dynamics of cellular reprogramming and accelerate the development of stem cell-based therapies.

Keywords: ; #adipose tissue; #Mesenchymal stem cells; #Hematopoietic stem cells; #Induced pluripotent stem cells; #Gene therapy; #Ethical considerations; #Safety; #Efficacy; #Personalized medicine; #Stem cell niche; #In vitro differentiation; #Biomaterials; #Stem cell banking; #Stem cell manufacturing; #Stem cell research

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Genetic Engineering & Bone Marrow Transplant

Genetic engineering plays a significant role in bone marrow transplantation, particularly in the context of hematopoietic stem cell transplantation (HSCT). HSCT is commonly used to treat various blood disorders and cancers. Genetic engineering techniques, such as gene editing using CRISPR-Cas9, offer the potential to modify the genetic makeup of donor cells or patient's own cells for therapeutic purposes.

By introducing specific genetic modifications, such as correcting disease-causing mutations or enhancing the cells' ability to fight against cancer cells, genetic engineering can enhance the efficacy and safety of bone marrow transplants. Additionally, genetic engineering can be utilized to improve the compatibility between the donor and recipient, reducing the risk of rejection and graft-versus-host disease.

The application of genetic engineering in bone marrow transplantation holds promise for improving outcomes and expanding the range of treatable conditions, offering new avenues for personalized and precise medicine approaches.

List of Journals: #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology; #Journal of Materials Science: Materials in Medicine; #Journal of Biomechanics; #Scientific Reports (Nature).

List of stem cell foundations and organizations: #Center for Regenerative Medicine, The Scripps Research Institute (United States); #Fred Hutchinson Cancer Research Center, Stem Cell and Gene Therapy Program (United States); #Centre for Stem Cell Research, A*STAR (Agency for Science, Technology, and Research) (Singapore)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Translational Research Opportunities In Stem Cell Studies

Translational research opportunities in stem cell studies are vast and hold great potential for bridging the gap between basic research and clinical applications. Stem cell research provides a foundation for developing novel therapies and advancing regenerative medicine. Translational research aims to translate scientific discoveries into practical applications that benefit patients.

Opportunities exist in various areas, including the development of stem cell-based therapies for diseases such as neurodegenerative disorders, cardiovascular conditions, and organ failure. Translational research also involves optimizing stem cell manufacturing processes, improving delivery methods, and addressing regulatory and ethical considerations.

Furthermore, collaborations between researchers, clinicians, industry partners, and regulatory bodies are essential to facilitate the translation of stem cell research findings into tangible clinical interventions. Translational research in stem cell studies has the potential to transform healthcare by providing innovative treatments and personalized medicine approaches to improve patient outcomes.

Keywords: #Stem cells; #Therapy; #Regenerative medicine; #Transplantation; #Cell-based therapy; #Tissue engineering; #Cell differentiation; #Cell replacement; #Disease treatment; #Cellular therapy; #Stem cell transplantation; #Stem cell-based regenerative therapy; #Immunomodulation; #Cell regeneration; #Clinical trials; #Stem cell sources

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Pluripotent Stem Cells

Pluripotent stem cells are a type of stem cell that has the remarkable ability to differentiate into any cell type in the human body. The most well-known and extensively studied type of pluripotent stem cell is the induced pluripotent stem cell (iPSC), which is generated by reprogramming adult cells back to an embryonic-like state.

Pluripotent stem cells hold tremendous potential for regenerative medicine, disease modeling, and drug discovery. They can be directed to differentiate into specific cell lineages, such as neurons, cardiomyocytes, or pancreatic cells, allowing researchers to study disease mechanisms and test potential therapies in a laboratory setting.

Moreover, pluripotent stem cells offer the possibility of personalized medicine by generating patient-specific cell lines for transplantation or drug screening, considering the individual's genetic background.

Continued research and understanding of pluripotent stem cells will contribute to advancing the field of regenerative medicine and expanding our knowledge of human development and disease.

Keywords: #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids; #Biofabrication

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Cellular Plasticity & Reprogramming

Cellular plasticity refers to the ability of cells to change their identity and function, often through a process called reprogramming. Reprogramming involves converting one cell type into another by altering its gene expression patterns and signaling pathways.

Cellular plasticity and reprogramming have significant implications in regenerative medicine and disease modeling. Induced pluripotent stem cells (iPSCs) exemplify cellular plasticity as they can be generated by reprogramming adult cells back to a pluripotent state. iPSCs can then be differentiated into various cell types, providing a valuable tool for studying disease mechanisms and developing personalized therapies.

Furthermore, cellular plasticity can occur naturally, such as during tissue regeneration or in response to injury, where cells can transdifferentiate and acquire new cell fates.

Understanding the mechanisms underlying cellular plasticity and reprogramming opens new avenues for regenerative medicine, allowing the manipulation of cells to replace damaged or diseased tissues and explore therapeutic interventions.

Keywords: #Tissue engineering; #Cell differentiation; #Cell replacement; #Disease treatment; #Cellular therapy; #Stem cell transplantation; #Stem cell-based regenerative therapy; #Immunomodulation; #Cell regeneration

List of Journals: #Tissue Engineering; #Biomaterials; #Journal of Stem Cell Research Therapy; #Cytotherapy; #Journal of Regenerative Medicine; #Current Stem Cell Research Therapy; #Stem Cell Research and Therapy; #Stem Cell Reviews and Reports

List of stem cell foundations and organizations:#California Institute for Regenerative Medicine (CIRM); #International Society for Stem Cell Research (ISSCR); #New York Stem Cell Foundation (NYSCF); #EuroStemCell; Stem Cell Network (SCN); #Alliance for Regenerative Medicine (ARM)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Hematopoietic Stem Cells

Hematopoietic stem cells (HSCs) are a type of adult stem cell found in the bone marrow that give rise to all blood cell types. They have the unique ability to self-renew and differentiate into various specialized cells, including red blood cells, white blood cells, and platelets.

HSCs play a vital role in the body's immune system, ensuring the continuous production of healthy blood cells throughout life. They are also used in hematopoietic stem cell transplantation (HSCT) to treat various blood disorders, such as leukemia, lymphoma, and certain genetic diseases.

The study of HSCs has provided valuable insights into developmental biology, immunology, and regenerative medicine. Understanding the mechanisms that regulate HSC self-renewal and differentiation has significant implications for developing novel therapies for blood-related diseases and improving transplantation outcomes.

List of Journals: #Science Translational Medicine; #PLOS ONE; #Acta Biomaterialia; #Biomaterials Science; #Advanced Healthcare Materials; #Advanced Drug Delivery Reviews; #Journal of Biomedical Materials Research Part A; #Regenerative Medicine; #Journal of Cellular and Molecular Medicine; #Journal of Biomaterials Applications

List of stem cell foundations and organizations: #Center for Stem Cell Research, University of Texas Health Science Center at Houston (United States); #RIKEN Center for Developmental Biology (Japan); #Center for Stem Cell Research, Chinese Academy of Sciences (China); #Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University (China)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in various tissues, including bone marrow, adipose tissue, and umbilical cord. MSCs possess the ability to differentiate into multiple cell types, including bone cells, cartilage cells, and fat cells.

MSCs have attracted significant attention in regenerative medicine due to their immunomodulatory properties and their potential to promote tissue repair and regeneration. They secrete bioactive molecules that can modulate the immune response, reduce inflammation, and stimulate tissue healing. This makes them valuable for treating conditions such as bone defects, cartilage injuries, and autoimmune diseases.

In addition, MSCs have been investigated for their potential in drug delivery, as they can be easily cultured and genetically modified to deliver therapeutic molecules to specific sites in the body.

The versatility and regenerative capabilities of MSCs make them a promising tool in regenerative medicine, holding potential for developing innovative treatments and improving patient outcomes.

Keywords: #Stem cell sources; #umbilical cord blood; #bone marrow; #adipose tissue; #Mesenchymal stem cells; #Hematopoietic stem cells; #Induced pluripotent stem cells; #Gene therapy; #Ethical considerations; #Safety; #Efficacy; #Personalized medicine; #Stem cell niche; #In vitro differentiation; #Biomaterials; #Stem cell banking

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cell Biomarkers

Stem cell biomarkers are specific molecular characteristics or features that can be used to identify and isolate stem cells from other cell types. These biomarkers serve as unique identifiers, allowing researchers to distinguish and study different populations of stem cells.

Various biomarkers are used to identify and characterize different types of stem cells. For example, surface markers like CD34 and CD133 are commonly used to isolate hematopoietic stem cells, while CD44 and CD90 are used to identify mesenchymal stem cells.

Biomarkers also play a crucial role in monitoring the differentiation and maturation of stem cells into specific cell lineages. Changes in the expression of biomarkers can indicate the progression of stem cells towards a particular cell type.

By understanding and utilizing stem cell biomarkers, researchers can better define and isolate specific populations of stem cells for various applications, including regenerative medicine, disease modeling, and drug discovery.

Keywords: #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation; #Biomimetic materials; #Tissue scaffolds; #Decellularization

List of stem cell foundations and organizations: #Harvard Stem Cell Institute (United States); #University of California, San Francisco (UCSF) Stem Cell Center (United States); #Center for Stem Cell Biology and Regenerative Medicine, Washington University in St. Louis (United States); #Centre for Stem Cells and Regenerative Medicine, King's College London (United Kingdom)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Immunomodulation in Tissue Engineering

Immunomodulation is a critical aspect of tissue engineering, which aims to create functional tissues and organs for transplantation or regenerative medicine. The immune response plays a significant role in tissue integration, acceptance, and long-term survival.

Immunomodulatory strategies are employed to regulate the immune system's response to transplanted or engineered tissues. This involves manipulating the interactions between the immune cells and the engineered constructs to promote immune tolerance and prevent rejection.

Various approaches are used for immunomodulation in tissue engineering, including the use of immunosuppressive drugs, biomaterial modifications, and incorporation of immunomodulatory cells, such as mesenchymal stem cells. These strategies aim to reduce inflammation, promote tissue integration, and enhance the functional longevity of engineered tissues.

By effectively modulating the immune response, tissue engineering approaches can enhance the success of tissue transplantation and improve patient outcomes in regenerative medicine applications.

Keywords: #Personalized medicine; #Stem cell niche; #In vitro differentiation; #Biomaterials; #Stem cell banking; #Stem cell manufacturing; #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids

List of stem cell foundations and organizations: #Center for Regenerative Medicine - Massachusetts General Hospital; #Stem Cell and Regenerative Medicine Center - University of Wisconsin-Madison; #Institute of Biomaterials and Biomedical Engineering - University of Toronto; #Center for Regenerative Therapies Dresden - Technische Universität Dresden; #Wake Forest Institute for Regenerative Medicine

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Induced Pluripotent Stem Cells (iPSCs)

Induced pluripotent stem cells (iPSCs) are a type of stem cell that are generated by reprogramming adult cells, such as skin cells or blood cells, back to a pluripotent state. This reprogramming is achieved by introducing specific genetic factors into the cells, which alters their gene expression patterns and allows them to regain the ability to differentiate into any cell type in the body.

iPSCs have revolutionized the field of regenerative medicine and disease modeling. They offer a patient-specific and ethically non-controversial source of pluripotent stem cells, bypassing the need for embryonic stem cells. iPSCs can be differentiated into various cell types, providing valuable tools for studying disease mechanisms, drug discovery, and personalized medicine.

Moreover, iPSCs hold promise for cell-based therapies, as they can potentially be used to generate patient-specific cells for transplantation, reducing the risk of immune rejection.

However, challenges remain, such as ensuring the safety and efficiency of reprogramming techniques, as well as addressing potential genetic and epigenetic variations in iPSCs. Ongoing research continues to refine iPSC generation methods and expand their potential applications in medicine and research.

Keywords: #Stem cell banking; #Stem cell manufacturing; #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation

List of Journals: #Current Stem Cell Research Therapy; #Stem Cell Research and Therapy; #Stem Cell Reviews and Reports; #Journal of Translational Medicine; #Molecular Therapy; #Frontiers in Cell and Developmental Biology; #Nature Communications; #Science Translational Medicine; #PLOS ONE; #Acta Biomaterialia.

List of stem cell foundations and organizations: #Center for Regenerative Medicine and Stem Cell Research - University of California, Davis; #Institute for Stem Cell Science and Regenerative Medicine - National Centre for Biological Sciences (India); #Center for Regenerative Medicine - Mayo Clinic; #McEwen Centre for Regenerative Medicine - University Health Network (Canada); #California Institute for Regenerative Medicine (CIRM); #International Society for Stem Cell Research (ISSCR)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Cell & Organ Regeneration

Cell and organ regeneration is a field of research and medicine that focuses on restoring damaged or diseased tissues and organs through the use of various cellular approaches. Stem cells play a central role in regenerative medicine, as they possess the ability to differentiate into different cell types and contribute to tissue repair and regeneration.

Through transplantation or stimulation of endogenous stem cells, regenerative therapies aim to replace or repair damaged cells, promote tissue healing, and restore organ function. This holds great potential for treating conditions such as heart disease, neurodegenerative disorders, liver failure, and spinal cord injuries.

Advancements in tissue engineering, biomaterials, and growth factor delivery systems further enhance the development of functional tissues and organs outside the body, which can be used for transplantation or as models for drug testing and disease research.

While significant progress has been made, challenges such as immune rejection, scalability, and precise control of cell differentiation and integration still need to be overcome for the widespread clinical application of cell and organ regeneration. Nonetheless, the field continues to advance, offering hope for improved treatments and improved quality of life for patients.

Keywords: #Stem cells; #Cell therapy; #Biomaterials; #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation; #Cellular therapy; #Bioprinting; #Organ transplantation; #Wound healing; #Biomarkers; #Disease modeling; #Clinical trials; #Personalized medicine

List of Journals: #Stem Cell Reports; #Cell Stem Cell; #Stem Cell Research; #Regenerative Medicine; #Tissue Engineering; #Biomaterials; #Journal of Stem Cell Research Therapy; #Cytotherapy; #Journal of Regenerative Medicine; #Current Stem Cell Research Therapy; #Stem Cell Research and Therapy; #Stem Cell Reviews and Reports; #Journal of Translational Medicine; #Molecular Therapy; #Frontiers in Cell and Developmental Biology

List of stem cell foundations and organizations: #Harvard Stem Cell Institute (United States); #University of California, San Francisco (UCSF) Stem Cell Center (United States); #Center for Stem Cell Biology and Regenerative Medicine, Washington University in St. Louis (United States); #Centre for Stem Cells and Regenerative Medicine, King's College London (United Kingdom)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cell Niches

Stem cell niches are specialized microenvironments within tissues that provide a supportive and regulated environment for the maintenance and function of stem cells. These niches consist of cellular and extracellular components that interact with stem cells to regulate their behavior, self-renewal, and differentiation.

The components of a stem cell niche include neighboring cells, extracellular matrix, signaling molecules, and physical factors. Niches can vary across different tissues and organs, providing specific cues and signals to control stem cell behavior.

The niche plays a crucial role in balancing stem cell self-renewal and differentiation, regulating stem cell quiescence or activation, and responding to tissue needs for regeneration or repair. Disruptions in the niche can affect stem cell function and contribute to disease progression.

Understanding the intricate interactions within stem cell niches is essential for harnessing the full potential of stem cells in regenerative medicine and tissue engineering applications. Researchers continue to explore the complexity of stem cell niches to optimize stem cell-based therapies and enhance tissue regeneration strategies.

Journals: #Regenerative Medicine; #Journal of Cellular and Molecular Medicine; #Journal of Biomaterials Applications; #Biotechnology Advances; #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology; #Journal of Materials Science: Materials in Medicine; #Journal of Biomechanics; #Scientific Reports (Nature)

List of stem cell foundations and organizations: #Wyss Institute for Biologically Inspired Engineering - Harvard University; #Center for Regenerative Medicine - Massachusetts General Hospital; #Stem Cell and Regenerative Medicine Center - University of Wisconsin-Madison; #Institute of Biomaterials and Biomedical Engineering - University of Toronto; #Center for Regenerative Therapies Dresden - Technische Universität Dresden; #Wake Forest Institute for Regenerative Medicine

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Vascularization and Angiogenesis

Vascularization and angiogenesis are processes that involve the formation of new blood vessels within tissues. These processes play a crucial role in tissue development, wound healing, and regenerative medicine.

Vascularization refers to the formation of a network of blood vessels within a tissue or organ. It is essential for supplying oxygen, nutrients, and growth factors to cells, as well as facilitating the removal of waste products. Vascularization is a critical factor in the success of tissue engineering, as engineered tissues need an adequate blood supply for survival and integration with the host tissue.

Angiogenesis, on the other hand, specifically refers to the sprouting and growth of new blood vessels from pre-existing ones. It is a complex process involving the activation of endothelial cells, migration, proliferation, and formation of new capillaries. Angiogenesis is tightly regulated by various signaling molecules and factors.

In regenerative medicine, strategies are employed to enhance vascularization and angiogenesis within engineered tissues. This can include the incorporation of pro-angiogenic factors, biomaterials that mimic the extracellular matrix, and the use of endothelial cells or progenitor cells to promote blood vessel formation.

Understanding and manipulating vascularization and angiogenesis are critical for the successful regeneration of complex tissues and organs, as well as for the development of therapeutic interventions to promote tissue healing and repair.

Keywords: #Stem cells; #Therapy; #Regenerative medicine; #Transplantation; #Cell-based therapy; #Tissue engineering; #Cell differentiation; #Cell replacement; #Disease treatment; #Cellular therapy; #Stem cell transplantation; #Stem cell-based regenerative therapy; #Immunomodulation; #Cell regeneration; #Clinical trials; #Stem cell sources; #umbilical cord blood; #bone marrow;

Journals: #Journal of Biomaterials Applications; #Biotechnology Advances; #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology; #Journal of Materials Science: Materials in Medicine; #Journal of Biomechanics; #Scientific Reports (Nature).

List of stem cell foundations and organizations: #Harvard Stem Cell Institute (United States); #University of California, San Francisco (UCSF) Stem Cell Center (United States); #Center for Stem Cell Biology and Regenerative Medicine, Washington University in St. Louis (United States); #Centre for Stem Cells and Regenerative Medicine, King's College London (United Kingdom); #MRC Centre for Regenerative Medicine, University of Edinburgh (United Kingdom)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Drugs and Clinical Developments

Drugs and clinical developments in the field of stem cells have the potential to revolutionize healthcare by providing new treatment options for various diseases and conditions. Stem cell-based therapies offer the possibility of regenerating damaged tissues, replacing dysfunctional cells, and modulating the immune system.

Clinical trials are underway to evaluate the safety and efficacy of stem cell-based treatments for conditions such as neurodegenerative diseases, cardiovascular disorders, autoimmune diseases, and organ transplantation.

In addition to stem cell transplantation, drugs targeting stem cell niches, growth factors, and signaling pathways are being developed to enhance the therapeutic potential of stem cells. These drugs aim to optimize stem cell survival, proliferation, and differentiation, ultimately improving patient outcomes.

The progress in stem cell research and drug development offers hope for patients with currently incurable conditions, paving the way for novel therapies and personalized medicine approaches. Continued research and clinical trials are necessary to establish the full potential of stem cell-based drugs and drive advancements in regenerative medicine.

List of Journals: #Biotechnology Advances; #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology; #Journal of Materials Science: Materials in Medicine; #Journal of Biomechanics; #Scientific Reports (Nature).

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cells in Developmental Biology

p >Stem cells play a pivotal role in developmental biology by contributing to the formation and growth of tissues and organs during embryonic development. Embryonic stem cells (ESCs) are derived from the inner cell mass of the early embryo and possess the unique ability to differentiate into any cell type in the body.

Studying stem cells in developmental biology helps unravel the intricate processes involved in tissue formation, organogenesis, and cell fate determination. It offers insights into the molecular and cellular mechanisms underlying normal development and can help elucidate the causes of developmental disorders and birth defects.

Furthermore, induced pluripotent stem cells (iPSCs) generated from adult cells enable the generation of patient-specific cell lines, facilitating disease modeling and drug screening.

By understanding the behavior and differentiation potential of stem cells, researchers can gain valuable insights into the fundamental principles of developmental biology and apply this knowledge to advance regenerative medicine and tissue engineering approaches.

Keywords: #Tissue engineering; #Stem cells; #Cell therapy; #Biomaterials; #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation; #Cellular therapy; #Bioprinting; #Organ transplantation; #Wound healing; #Biomarkers; #Disease modeling; #Clinical trials; #Personalized medicine

List of Journals: #Science Translational Medicine; #PLOS ONE; #Acta Biomaterialia; #Biomaterials Science; #Advanced Healthcare Materials; #Advanced Drug Delivery Reviews; #Regenerative Medicine; #Journal of Cellular and Molecular Medicine; #Journal of Biomaterials Applications; #Biotechnology Advances; #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells;

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cells and Aging

Stem cells and aging are intricately connected. As individuals age, the regenerative capacity of stem cells declines, leading to impaired tissue repair and an increased susceptibility to age-related diseases. The functional decline of stem cells is attributed to various factors, including changes in the stem cell niche, accumulation of DNA damage, and alterations in epigenetic regulation.

Age-associated changes in stem cells contribute to the development of degenerative diseases such as Alzheimer's, Parkinson's, and cardiovascular disorders. Understanding the mechanisms underlying stem cell aging is crucial for developing strategies to rejuvenate or enhance the function of aging stem cells.

Researchers are investigating ways to modulate the aging process in stem cells, including interventions such as genetic manipulation, pharmacological treatments, and lifestyle modifications. These efforts aim to harness the regenerative potential of stem cells and mitigate the effects of aging, ultimately promoting healthier aging and extending the quality of life.

Keywords: #Biomaterials; #Stem cell banking; #Stem cell manufacturing; #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation; #Biomimetic materials; #Tissue scaffolds; #Decellularization

Journals: #Stem Cell Reports; #Cell Stem Cell; #Stem Cell Research; #Regenerative Medicine; #Tissue Engineering; #Biomaterials; #Journal of Stem Cell Research Therapy; #Cytotherapy; #Journal of Regenerative Medicine; #Current Stem Cell Research Therapy; #Stem Cell Research and Therapy; #Stem Cell Reviews and Reports

List of stem cell foundations and organizations: #Alliance for Regenerative Medicine (ARM); #National Stem Cell Foundation (NSCF); #Stem Cell Foundation (Australia); #Stem Cell Regenerative Medicine Consortium (SRMC); #Massachusetts Stem Cell Bank and Registry; #German Stem Cell Network (GSCN); #Stem Cell Society Singapore.

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Biomimetic Tissue Models

Biomimetic tissue models are engineered constructs that aim to replicate the structural, functional, and biochemical characteristics of native tissues in a laboratory setting. These models provide a platform for studying tissue development, disease progression, and drug testing.

By mimicking the microenvironment and cellular interactions of natural tissues, biomimetic models offer a more physiologically relevant and predictive system for studying biological processes. They can be designed to incorporate various cell types, extracellular matrices, and biochemical cues to replicate the complexity of native tissues.

Biomimetic tissue models have the potential to revolutionize drug discovery and personalized medicine by enabling more accurate assessment of drug efficacy and toxicity, reducing the reliance on animal models, and facilitating the development of targeted therapies.

Continued advancements in biomaterials, tissue engineering techniques, and stem cell technologies are driving the development of increasingly sophisticated biomimetic tissue models, contributing to improved understanding of tissue function and disease mechanisms.

Keywords: #Tissue scaffolds; #Decellularization; #Tissue morphogenesis; #Bioreactors; #Vascularization; #Immunomodulation; #Tissue engineering; #Stem cells; #Cell therapy; #Biomaterials; #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation; #Cellular therapy

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cells and Veterinary Applications

Stem cells have shown great promise in veterinary medicine for a wide range of applications. Veterinary stem cell therapies involve the use of stem cells to treat injuries, promote tissue regeneration, and improve the quality of life for animals.

Common veterinary applications of stem cells include the treatment of orthopedic conditions such as osteoarthritis, tendon and ligament injuries, and bone fractures. Stem cells can also be used to aid in wound healing, manage inflammatory bowel disease, and support cardiac tissue repair.

The use of stem cells in veterinary medicine offers a non-invasive and potentially effective treatment option for animals, particularly in cases where traditional therapies have limited success. Ongoing research and clinical trials continue to explore the full potential of stem cells in veterinary applications, improving the health and well-being of companion animals and livestock.

Keywords: #Stem cell manufacturing; #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation; #Biomimetic materials; #Tissue scaffolds; #Decellularization; #Tissue morphogenesis

List of stem cell foundations and organizations:#Center for Regenerative Medicine and Stem Cell Research - University of California, Davis; #Institute for Stem Cell Science and Regenerative Medicine - National Centre for Biological Sciences (India); #Center for Regenerative Medicine - Mayo Clinic; #McEwen Centre for Regenerative Medicine - University Health Network (Canada); #California Institute for Regenerative Medicine (CIRM); #International Society for Stem Cell Research (ISSCR)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cells and Immune System

Stem cells play a crucial role in regulating and interacting with the immune system. The immune system, comprising various cells and molecules, protects the body against pathogens and foreign substances. Stem cells contribute to immune function in several ways.

Hematopoietic stem cells (HSCs) are responsible for generating all blood cells, including immune cells such as lymphocytes, macrophages, and dendritic cells. These immune cells are essential for immune surveillance, antigen presentation, and the initiation of immune responses.

Additionally, mesenchymal stem cells (MSCs) possess immunomodulatory properties. They can suppress immune responses, regulate inflammation, and promote tissue repair. MSCs have shown potential in treating immune-related disorders such as graft-versus-host disease and autoimmune conditions.

Stem cell-based therapies are being explored to modulate immune responses, enhance tissue regeneration, and improve transplant outcomes. Understanding the intricate interactions between stem cells and the immune system is crucial for harnessing their full potential in immunotherapy, regenerative medicine, and immune-related disorders.

List of stem cell foundations and organizations: #Alliance for Regenerative Medicine (ARM); #National Stem Cell Foundation (NSCF); #Stem Cell Foundation (Australia); #Stem Cell Regenerative Medicine Consortium (SRMC); #Massachusetts Stem Cell Bank and Registry; #German Stem Cell Network (GSCN); #Stem Cell Society Singapore.

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cells and Biomaterials

The combination of stem cells and biomaterials has emerged as a powerful approach in regenerative medicine. Biomaterials provide a supportive environment for stem cell growth, differentiation, and tissue formation. They can serve as scaffolds, delivering stem cells to specific sites, providing mechanical support, and promoting cell attachment and migration.

Biomaterials can be engineered to mimic the extracellular matrix (ECM) of native tissues, providing cues for stem cell behavior and directing their differentiation into desired cell types. They can also be loaded with growth factors, cytokines, and other bioactive molecules to enhance stem cell functions and tissue regeneration.

Stem cells, on the other hand, can enhance the functionality of biomaterials by contributing to tissue formation, secreting factors that promote healing and modulating the immune response.

The synergy between stem cells and biomaterials has led to significant advancements in tissue engineering, wound healing, and organ transplantation. The development of innovative biomaterials and optimization of stem cell-biomaterial interactions hold great potential for creating functional and clinically relevant tissue constructs.

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Cell Differentiation & Disease Modelling

Cell differentiation and disease modeling are closely intertwined fields that rely on the use of stem cells. Stem cells, particularly induced pluripotent stem cells (iPSCs), can be directed to differentiate into specific cell types, providing a valuable tool for studying disease mechanisms and developing potential therapies.

By differentiating iPSCs into disease-relevant cell types, researchers can create cellular models that closely mimic the characteristics of the disease. These models enable the study of disease progression, identification of disease-specific biomarkers, and evaluation of drug responses.

Cell differentiation and disease modeling also offer insights into the underlying molecular and cellular processes of diseases, aiding in the development of targeted therapeutics and personalized medicine approaches.

Moreover, disease modeling with stem cells has the potential to replace or reduce the reliance on animal models, allowing for more ethical and accurate research.

Continued advancements in stem cell technology and differentiation protocols are enhancing the fidelity and applicability of cell differentiation and disease modeling, ultimately contributing to a deeper understanding of various diseases and facilitating the development of effective treatments.

Keywords: #Tissue morphogenesis; #Immunomodulation; #Tissue engineering; #Stem cells; #Cell therapy; #Biomaterials; #Regeneration; #Repair; #Transplantation; #Scaffold; #Growth factors; #Gene therapy; #Tissue regeneration; #Immunomodulation; #Cellular therapy; #Bioprinting; #Organ transplantation; #Wound healing; #Biomarkers; #Disease modeling; #Clinical trials; #Personalized medicine

List of stem cell foundations and organizations: #Center for Cellular and Molecular Engineering - University of Pittsburgh; #Institute of Stem Cell Biology and Regenerative Medicine - Stanford University; #Center for Regenerative Medicine and Stem Cell Research - University of California, Davis; #Institute for Stem Cell Science and Regenerative Medicine - National Centre for Biological Sciences (India); #Center for Regenerative Medicine - Mayo Clinic; #McEwen Centre for Regenerative Medicine - University Health Network (Canada)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Stem Cell Banking and Ethics

Stem cell banking raises important ethical considerations that revolve around the source, ownership, and use of stem cells. One ethical concern is the collection of embryonic stem cells, as it involves the destruction of embryos. This raises debates regarding the moral status of the embryo and the ethical implications of using embryonic stem cells in research or therapeutic applications.

Another aspect is the issue of informed consent and ensuring that individuals fully understand the implications of storing their own stem cells or those of their children in stem cell banks. Transparency, privacy, and equitable access to stem cell banking services are also ethical concerns.

Ethical guidelines and regulations have been developed to address these concerns, promoting responsible and ethical practices in stem cell banking. These guidelines emphasize obtaining informed consent, protecting donor rights, ensuring the proper handling and storage of stem cells, and promoting transparency in advertising and information provision.

Ongoing discussions and ethical debates in the field are crucial for establishing guidelines that balance the potential benefits of stem cell banking with the ethical considerations associated with its practice.

Keywords: #Stem cells; #Therapy; #Regenerative medicine; #Cell-based therapy; #Tissue engineering; #Cell differentiation; #Cell replacement; #Disease treatment; #Cellular therapy; #Stem cell transplantation; #Stem cell-based regenerative therapy; #Immunomodulation; #Cell regeneration; #Clinical trials; #Stem cell sources; #umbilical cord blood; #bone marrow; #adipose tissue; #Mesenchymal stem cells; #Hematopoietic stem cells; #Induced pluripotent stem cells; #Gene therapy

List of Journals: #Stem Cell Reports; #Cell Stem Cell; #Stem Cell Research; #Regenerative Medicine; #Tissue Engineering; #Biomaterials; #Journal of Stem Cell Research Therapy; #Cytotherapy; #Journal of Regenerative Medicine; #Current Stem Cell Research Therapy; #Stem Cell Research and Therapy; #Stem Cell Reviews and Reports; #Journal of Translational Medicine; #Molecular Therapy; #Frontiers in Cell and Developmental Biology

List of stem cell foundations and organizations: #Harvard Stem Cell Institute (United States); #University of California, San Francisco (UCSF) Stem Cell Center (United States); #Center for Stem Cell Biology and Regenerative Medicine, Washington University in St. Louis (United States); #Centre for Stem Cells and Regenerative Medicine, King's College London (United Kingdom); #MRC Centre for Regenerative Medicine, University of Edinburgh (United Kingdom)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Bio fabrication and 3D Printing

Biofabrication and 3D printing have revolutionized the field of tissue engineering and regenerative medicine. These technologies allow for the precise fabrication of complex three-dimensional structures using biomaterials and living cells.

Biofabrication combines advanced manufacturing techniques with biological components to create functional tissues and organs. It involves the precise deposition of cells, biomaterials, and bioactive factors layer by layer to mimic the architecture and functionality of native tissues.

3D printing, or additive manufacturing, enables the creation of patient-specific constructs with high precision and customization. It allows for the fabrication of scaffolds, organs, and tissues with intricate geometries, providing a platform for tissue regeneration and transplantation.

Biofabrication and 3D printing offer numerous benefits, including reduced waiting times for organ transplantation, enhanced drug testing platforms, and personalized healthcare solutions. They also provide opportunities for disease modeling, the development of implantable devices, and the advancement of in vitro drug screening.

As these technologies continue to evolve, they hold the potential to transform the field of medicine by enabling the creation of functional tissues and organs on demand, addressing the critical shortage of donor organs, and improving patient outcomes.

List of Journals: #Stem Cell Reports; #Cell Stem Cell; #Stem Cell Research; #Regenerative Medicine; #Tissue Engineering; #Biomaterials; #Journal of Stem Cell Research Therapy; #Cytotherapy; #Journal of Regenerative Medicine; #Current Stem Cell Research Therapy; #Stem Cell Research and Therapy; #Stem Cell Reviews and Reports; #Journal of Translational Medicine; #Molecular Therapy; #Frontiers in Cell and Developmental Biology

List of stem cell foundations and organizations: #Harvard Stem Cell Institute (United States); #University of California, San Francisco (UCSF) Stem Cell Center (United States); #Center for Stem Cell Biology and Regenerative Medicine, Washington University in St. Louis (United States); #Centre for Stem Cells and Regenerative Medicine, King's College London (United Kingdom); #MRC Centre for Regenerative Medicine, University of Edinburgh (United Kingdom)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Combating COVID-19 with stem cell therapy

Stem cell therapy has emerged as a potential approach for combating COVID-19, the respiratory illness caused by the SARS-CoV-2 virus. Stem cells possess unique immunomodulatory properties and the ability to promote tissue repair and regeneration, making them promising candidates for COVID-19 treatment.

Stem cell therapy aims to modulate the excessive immune response, known as cytokine storm, which can cause severe lung damage in COVID-19 patients. By suppressing inflammation and promoting tissue healing, stem cells may help alleviate respiratory symptoms and improve patient outcomes.

Early clinical trials and case studies have shown promising results, with some patients experiencing reduced lung inflammation, improved oxygenation, and faster recovery after receiving stem cell therapy.

However, further research is needed to establish the safety, efficacy, and optimal dosing of stem cell therapy for COVID-19. Ongoing studies are investigating different types of stem cells, including mesenchymal stem cells, for their potential in combating this global pandemic.

Keywords: #Stem cells; #Therapy; #Regenerative medicine; #Transplantation; #Cell-based therapy; #Tissue engineering; #Cell differentiation; #Cell replacement; #Disease treatment; #Cellular therapy; #Stem cell transplantation; #Stem cell-based regenerative therapy; #Immunomodulation; #Cell regeneration; #Clinical trials; #Stem cell sources; #umbilical cord blood; #bone marrow; #adipose tissue; #Mesenchymal stem cells; #Hematopoietic stem cells

List of stem cell foundations and organizations: #Harvard Stem Cell Institute (United States); #University of California, San Francisco (UCSF) Stem Cell Center (United States); #Center for Stem Cell Biology and Regenerative Medicine, Washington University in St. Louis (United States); #Centre for Stem Cells and Regenerative Medicine, King's College London (United Kingdom); #MRC Centre for Regenerative Medicine, University of Edinburgh (United Kingdom)

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Organ-on-a-Chip Systems

Organ-on-a-chip systems are innovative platforms that aim to replicate the structure and functions of human organs in a microscale format. These systems integrate living cells, biomaterials, and microfluidics to create micro physiological models that mimic the behavior of specific organs.

Organ-on-a-chip technology offers several advantages over traditional cell culture and animal models. It provides a more accurate representation of human physiology, enabling the study of organ-level responses to drugs, toxins, and diseases in a controlled environment.

These systems have the potential to revolutionize drug discovery, toxicity testing, and personalized medicine by providing a platform for rapid and cost-effective screening of drug candidates and predicting individual patient responses to treatment.

Organ-on-a-chip models can also be interconnected to simulate interactions between multiple organs, allowing for the study of complex diseases and systemic responses.

As research in this field progresses, organ-on-a-chip systems hold promise for advancing our understanding of organ function, disease mechanisms, and therapeutic interventions.

Keywords: #In vitro differentiation; #Biomaterials; #Stem cell banking; #Stem cell manufacturing; #Stem cell research; #Tissue engineering; #Regenerative medicine; #Biomaterials; #Scaffold; #Stem cells; #Cell-based therapy; #Extracellular matrix; #Tissue regeneration; #3D bioprinting; #Organoids; #Biofabrication; #Tissue culture; #Cell differentiation; #Biomimetic materials; #Tissue scaffolds; #Decellularization; #Tissue morphogenesis; #Bioreactors; #Vascularization; #Immunomodulation

List of Journals: #Advanced Healthcare Materials; #Advanced Drug Delivery Reviews; #Journal of Biomedical Materials Research Part A; #Regenerative Medicine; #Journal of Cellular and Molecular Medicine; #Journal of Biomaterials Applications; #Biotechnology Advances; #Tissue Engineering Part A; #Journal of Tissue Engineering and Regenerative Medicine; #Cells; #Frontiers in Bioengineering and Biotechnology; #Journal of Materials Science: Materials in Medicine; #Journal of Biomechanics; #Scientific Reports (Nature).

List of stem cell foundations and organizations: #RIKEN Center for Developmental Biology (Japan); #Center for Stem Cell Research, Chinese Academy of Sciences (China); #Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University (China); #Institute of Bioengineering and Stem Cells, KU Leuven (Belgium); #Australian Regenerative Medicine Institute (ARMI); #Monash University (Australia); #Center for Regenerative Medicine, The Scripps Research Institute (United States);

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Biomaterials and Scaffold Design

Biomaterials and scaffold design play a crucial role in tissue engineering and regenerative medicine. Biomaterials are materials specifically engineered to interact with biological systems, while scaffolds are three-dimensional structures that provide support for cell attachment, growth, and tissue regeneration.

Biomaterials used in scaffold design can be synthetic or derived from natural sources, such as polymers, hydrogels, or decellularized extracellular matrices. These materials can be tailored to possess desired mechanical, chemical, and biological properties.

The design of scaffolds involves considerations such as porosity, pore size, surface topography, and degradation kinetics. These factors influence cell behavior, nutrient and oxygen diffusion, and the formation of new tissue.

Optimal scaffold design facilitates cell adhesion, proliferation, and differentiation, promoting the regeneration of functional tissues. Additionally, biomaterials and scaffold design contribute to controlled drug delivery, enabling the release of bioactive factors to enhance tissue healing and regeneration.

Continued advancements in biomaterials and scaffold design techniques are driving the development of more effective and biomimetic platforms for tissue engineering and regenerative medicine applications.

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics.

Clinical Translation and Commercialization

Clinical translation and commercialization are critical steps in bringing stem cell therapies and regenerative medicine technologies from the laboratory to clinical practice. These processes involve the transition from preclinical research to human clinical trials and eventual market availability.

Clinical translation requires rigorous testing of safety, efficacy, and quality control in human subjects. It involves conducting well-designed clinical trials to evaluate the therapeutic potential of stem cell-based interventions and their impact on patient outcomes. The trials provide crucial data on dosage, administration methods, and long-term safety.

Commercialization involves the successful navigation of regulatory pathways, intellectual property protection, manufacturing scale-up, and market approval. It requires collaboration between researchers, regulatory authorities, funding agencies, and industry partners.

The commercialization of stem cell therapies and regenerative medicine technologies holds the potential to transform healthcare by providing novel treatments for previously incurable diseases and addressing unmet medical needs. However, it also involves challenges, including high development costs, regulatory complexities, and ethical considerations.

Efforts are being made to streamline and expedite the translation and commercialization processes, ensuring that safe and effective stem cell therapies reach patients in a timely manner while maintaining high standards of scientific and ethical integrity.

Key players: #Novartis; #Mesoblast Limited; #Fate Therapeutics; #ViaCyte; #BlueRock Therapeutics; #Gamida Cell; #Pluristem Therapeutics; #Celgene; #Athersys; #Cynata Therapeutics

Scientific Track

Stem Cell Therapy

Stem Cell Embryology

Stem Cell Banking

Stem Cells Beat COVID-19

Stem Cell Nanotechnology

Stem Cell Biotechnology and Cloning

Epigenetics and Genetics of Stem Cells

Stem Cell Apoptosis & Signal Transduction

Stem Cells in Disease and Treatment

Regenerative Medicine and Tissue Engineering

Stem Cell Bioengineering

Stem Cell & Pediatric Transplantation

Stem Cell-Based Drug Discovery

Regeneration & Therapeutics

Diseases and Stem Cell Treatment

Cancer Stem Cell and Oncology

Novel Stem Cell Technologies

Reprogramming Stem Cells: Computational Biology

Genetic Engineering & Bone Marrow Transplant

Translational Research Opportunities In Stem Cell Studies

Pluripotent Stem Cells

Cellular Plasticity & Reprogramming

Hematopoietic Stem Cells

Mesenchymal Stem Cells

Stem Cell Biomarkers

Immunomodulation in Tissue Engineering

Induced Pluripotent Stem Cells (iPSCs)

Cell & Organ Regeneration

Stem Cell Niches

Vascularization and Angiogenesis

Drugs and Clinical Developments

Stem Cells in Developmental Biology

Stem Cells and Aging

Biomimetic Tissue Models

Stem Cells and Veterinary Applications

Stem Cells and Immune System

Stem Cells and Biomaterials

Cell Differentiation & Disease Modelling

Stem Cell Banking and Ethics

Bio fabrication and 3D Printing

Combating COVID-19 with stem cell therapy

Organ-on-a-Chip Systems

Biomaterials and Scaffold Design

Clinical Translation and Commercialization

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